Effect of p53 activation through targeting MDM2/MDM4 heterodimer on T regulatory and effector cells in the peripheral blood of Type 1 diabetes patients

Various immunotherapies for the treatment of type 1 diabetes are currently under investigation. Some of these aim to rescue the remaining beta cells from autoimmune attack caused by the disease. Among the strategies employed, p53 has been envisaged as a possible target for immunomodulation. We studi...

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Publicado no:PLoS One
Main Authors: Pellegrino, Marsha, Traversi, Gianandrea, Arena, Andrea, Cappa, Marco, Rosado, M. Manuela, Andreani, Marco, Delfino, Domenico V., Moretti, Fabiola, Fierabracci, Alessandra
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988923/
https://ncbi.nlm.nih.gov/pubmed/31995625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228296
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