Pyrazole C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists

A series of 1-substituted 3-(t-butyl/trifluoromethyl)pyrazole C-region analogues of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides were investigated for hTRPV1 antagonism. The structure activity relationship indicated that the 3-chlorophenyl group at the 1-position of pyrazole was the optimized...

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Published in:Bioorg Med Chem Lett
Main Authors: Lee, Sunho, Kim, Changhoon, Ann, Jihyae, Thorat, Shivaji A., Kim, Eunhye, Park, Jongmi, Choi, Sun, Blumberg, Peter M., Frank-Foltyn, Robert, Bahrenberg, Gregor, Stockhausen, Hannelore, Christoph, Thomas, Lee, Jeewoo
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988736/
https://ncbi.nlm.nih.gov/pubmed/28838698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.08.020
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