2-Aryl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists

A series of 2-aryl pyridine C-region derivatives of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides were investigated as hTRPV1 antagonists. Multiple compounds showed highly potent TRPV1 antagonism toward capsaicin comparable to previous lead 7. Among them, compound 9 demonstrated anti-allodyni...

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Vydáno v:Bioorg Med Chem Lett
Hlavní autoři: Ryu, HyungChul, Seo, Sejin, Kim, Myeong Seop, Kim, Mi-Yeon, Kim, Ho Shin, Ann, Jihyae, Tran, Phuong-Thao, Hoang, Van-Hai, Byun, Jieun, Cui, Minghua, Son, Karam, Sharma, Pankaz Kumar, Choi, Sun, Blumberg, Peter M., Frank-Foltyn, Robert, Bahrenberg, Gregor, Koegel, Babette-Yvonne, Christoph, Thomas, Frormann, Sven, Lee, Jeewoo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980356/
https://ncbi.nlm.nih.gov/pubmed/25011915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.05.072
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