Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells

How chromosome organization is related to genome function remains poorly understood. Cohesin, loop extrusion, and CCCTC-binding factor (CTCF) have been proposed to create topologically associating domains (TADs) to regulate gene expression. Here, we examine chromosome conformation in embryonic stem...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Rhodes, James D.P., Feldmann, Angelika, Hernández-Rodríguez, Benjamín, Díaz, Noelia, Brown, Jill M., Fursova, Nadezda A., Blackledge, Neil P., Prathapan, Praveen, Dobrinic, Paula, Huseyin, Miles K., Szczurek, Aleksander, Kruse, Kai, Nasmyth, Kim A., Buckle, Veronica J., Vaquerizas, Juan M., Klose, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988126/
https://ncbi.nlm.nih.gov/pubmed/31968256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.12.057
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