Extra-Large Gα Protein (XLαs) Deficiency Causes Severe Adenine-Induced Renal Injury with Massive FGF23 Elevation

Fibroblast growth factor-23 (FGF23) is critical for phosphate and vitamin D homeostasis. Cellular and molecular mechanisms underlying FGF23 production remain poorly defined. The extra-large Gα subunit (XLαs) is a variant of the stimulatory G protein alpha-subunit (Gsα), which mediates the stimulator...

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Bibliographic Details
Published in:Endocrinology
Main Authors: Matthias, Julia, Cui, Qiuxia, Shumate, Lauren T, Plagge, Antonius, He, Qing, Bastepe, Murat
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986553/
https://ncbi.nlm.nih.gov/pubmed/31758181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/endocr/bqz025
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