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The G protein α-subunit variant XLαs promotes G(q/11)-dependent signaling and mediates the renal actions of parathyroid hormone in vivo
GNAS, which encodes the stimulatory G protein α subunit (Gαs), also encodes a large variant of Gαs termed XLαs, and alterations in XLαs abundance or activity are implicated in various human disorders. Although XLαs, like Gαs, stimulates generation of the second messenger cAMP, evidence suggests that...
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| Publicado no: | Sci Signal |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4618482/ https://ncbi.nlm.nih.gov/pubmed/26307011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaa9953 |
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