MON-LB087 Synthesis of Osteocyte-Derived Phosphaturic Hormone FGF23 via IP3/PKC Signaling Downstream of the Extra-Large Gα Subunit (XLαs)

Dysregulated actions of the bone-derived phosphaturic hormone FGF23 result in several inherited diseases and contribute substantially to the morbidity and mortality in renal failure. Molecular mechanisms governing FGF23 production are poorly defined. Parathyroid hormone (PTH) can stimulate FGF23 pro...

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Vydáno v:J Endocr Soc
Hlavní autoři: He, Qing, Shumate, Lauren, Matthias, Julia, Aydin, Cumhur, Wein, Marc, Spatz, Jordan, Plagge, Antonius, Divieti Pajevic, Paola, Bastepe, Murat
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2019
Témata:
Bone and Mineral Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6550714/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-MON-LB087
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