FocAn: automated 3D analysis of DNA repair foci in image stacks acquired by confocal fluorescence microscopy

BACKGROUND: Phosphorylated histone H2AX, also known as γH2AX, forms μm-sized nuclear foci at the sites of DNA double-strand breaks (DSBs) induced by ionizing radiation and other agents. Due to their specificity and sensitivity, γH2AX immunoassays have become the gold standard for studying DSB induct...

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Bibliographic Details
Published in:BMC Bioinformatics
Main Authors: Memmel, Simon, Sisario, Dmitri, Zimmermann, Heiko, Sauer, Markus, Sukhorukov, Vladimir L., Djuzenova, Cholpon S., Flentje, Michael
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
Subjects:
Methodology Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986076/
https://ncbi.nlm.nih.gov/pubmed/31992200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-020-3370-8
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