FocAn: automated 3D analysis of DNA repair foci in image stacks acquired by confocal fluorescence microscopy

BACKGROUND: Phosphorylated histone H2AX, also known as γH2AX, forms μm-sized nuclear foci at the sites of DNA double-strand breaks (DSBs) induced by ionizing radiation and other agents. Due to their specificity and sensitivity, γH2AX immunoassays have become the gold standard for studying DSB induct...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:BMC Bioinformatics
Prif Awduron: Memmel, Simon, Sisario, Dmitri, Zimmermann, Heiko, Sauer, Markus, Sukhorukov, Vladimir L., Djuzenova, Cholpon S., Flentje, Michael
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2020
Pynciau:
Methodology Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986076/
https://ncbi.nlm.nih.gov/pubmed/31992200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-020-3370-8
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