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Systemic Safety of a Recombinant AAV8 Vector for Human Cocaine Hydrolase Gene Therapy: A Good Laboratory Practice Preclinical Study in Mice

Cocaine addiction continues to impose major burdens on affected individuals and broader society but is highly resistant to medical treatment or psychotherapy. This study was undertaken with the goal of Food and Drug Administration (FDA) permission for a first-in-human clinical trial of a gene therap...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Hum Gene Ther
Hauptverfasser: Chen, Vicky Ping, Gao, Yang, Geng, Liyi, Steele, Mike, Jenks, Nathan, Peng, Kah-Whye, Brimijoin, Stephen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc., publishers 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985763/
https://ncbi.nlm.nih.gov/pubmed/31650869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2019.233
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