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Cocaine Hydrolase Gene Transfer Demonstrates Cardiac Safety and Efficacy against Cocaine-Induced QT Prolongation in Mice

Cocaine addiction is associated with devastating medical consequences, including cardiotoxicity and risk-conferring prolongation of the QT interval. Viral gene transfer of cocaine hydrolase engineered from butyrylcholinesterase offers therapeutic promise for treatment-seeking drug users. Although pr...

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Detalles Bibliográficos
Publicado en:J Pharmacol Exp Ther
Main Authors: Murthy, Vishakantha, Reyes, Santiago, Geng, Liyi, Gao, Yang, Brimijoin, Stephen
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767396/
https://ncbi.nlm.nih.gov/pubmed/26669428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.228825
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