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Modeling Polyglutamine Expansion Diseases with Induced Pluripotent Stem Cells

Polyglutamine expansion disorders, which include Huntington’s disease, have expanded CAG repeats that result in polyglutamine expansions in affected proteins. How this specific feature leads to distinct neuropathies in 11 different diseases is a fascinating area of investigation. Most proteins affec...

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Publicado en:Neurotherapeutics
Main Authors: Naphade, Swati, Tshilenge, Kizito-Tshitoko, Ellerby, Lisa M.
Formato: Artigo
Idioma:Inglês
Publicado: Springer International Publishing 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985408/
https://ncbi.nlm.nih.gov/pubmed/31792895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-019-00810-8
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