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Modeling Polyglutamine Expansion Diseases with Induced Pluripotent Stem Cells

Polyglutamine expansion disorders, which include Huntington’s disease, have expanded CAG repeats that result in polyglutamine expansions in affected proteins. How this specific feature leads to distinct neuropathies in 11 different diseases is a fascinating area of investigation. Most proteins affec...

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Bibliographic Details
Published in:Neurotherapeutics
Main Authors: Naphade, Swati, Tshilenge, Kizito-Tshitoko, Ellerby, Lisa M.
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985408/
https://ncbi.nlm.nih.gov/pubmed/31792895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-019-00810-8
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