SIRT1 Knockdown Enhances the Differentiation of Human Embryonic Stem Cells into Pancreatic β Cells

Nicotinamide is used to maturate pancreatic progenitors from embryonic stem cells (ESCs) into insulin-producing cells (IPCs). It has been known that nicotinamide inhibits the enzymatic activity of SIRT1, an NAD(+)-dependent deacetylase. Here we show that SIRT1 knockdown enhances the differentiation...

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Bibliografiske detaljer
Udgivet i:Dev Reprod
Main Authors: Seo, Nan-Hee, Song, Hwa-Ryung, Han, Myung-Kwan
Format: Artigo
Sprog:Inglês
Udgivet: Korean Society of Developmental Biology 2019
Fag:
Short Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985299/
https://ncbi.nlm.nih.gov/pubmed/31993545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12717/DR.2019.23.4.391
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