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SIRT1 Knockdown Enhances the Differentiation of Human Embryonic Stem Cells into Pancreatic β Cells
Nicotinamide is used to maturate pancreatic progenitors from embryonic stem cells (ESCs) into insulin-producing cells (IPCs). It has been known that nicotinamide inhibits the enzymatic activity of SIRT1, an NAD(+)-dependent deacetylase. Here we show that SIRT1 knockdown enhances the differentiation...
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| Pubblicato in: | Dev Reprod |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Korean Society of Developmental Biology
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6985299/ https://ncbi.nlm.nih.gov/pubmed/31993545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12717/DR.2019.23.4.391 |
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