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Strategies to Target ISG15 and USP18 Toward Therapeutic Applications
The interferon (IFN)-stimulated gene product 15 (ISG15) represents an ubiquitin-like protein (Ubl), which in a process termed ISGylation can be covalently linked to target substrates via a cascade of E1, E2, and E3 enzymes. Furthermore, ISG15 exerts functions in its free form both, as an intracellul...
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| Publicado en: | Front Chem |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6985271/ https://ncbi.nlm.nih.gov/pubmed/32039148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2019.00923 |
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