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Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance
Protein modification by the ubiquitin-like protein ISG15 is an interferon (IFN) effector system, which plays a major role in antiviral defense. ISG15 modification is counteracted by the isopeptidase USP18, a major negative regulator of IFN signaling, which was also shown to exert its regulatory func...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4321242/ https://ncbi.nlm.nih.gov/pubmed/25605921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412881112 |
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