Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance

Protein modification by the ubiquitin-like protein ISG15 is an interferon (IFN) effector system, which plays a major role in antiviral defense. ISG15 modification is counteracted by the isopeptidase USP18, a major negative regulator of IFN signaling, which was also shown to exert its regulatory func...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Ketscher, Lars, Hannß, Ronny, Morales, David J., Basters, Anja, Guerra, Susana, Goldmann, Tobias, Hausmann, Annika, Prinz, Marco, Naumann, Ronald, Pekosz, Andrew, Utermöhlen, Olaf, Lenschow, Deborah J., Knobeloch, Klaus-Peter
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321242/
https://ncbi.nlm.nih.gov/pubmed/25605921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412881112
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