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Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity
Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T cell priming against foreign antigens. Polioviruses can provide a context optimal for generating antigen-specific CD8 T cells, as they have natural tropism for dendritic cells, preeminent inducers of CD8 T cell...
Uloženo v:
| Vydáno v: | Nat Commun |
|---|---|
| Hlavní autoři: | , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6985231/ https://ncbi.nlm.nih.gov/pubmed/31988324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13939-z |
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