THER-05. GENETICALLY STABLE POLIOVIRUS VECTOR CARRYING H3.3K27M ANTIGEN FOR TREATMENT OF DIFFUSE MIDLINE GLIOMA BY INTRAMUSCULAR INJECTION

BACKGROUND: H3 K27M-mutant diffuse midline glioma (DMG) is invariably lethal. Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T cell priming against foreign antigens. Polioviruses, in particular, are uniquely tropic for dendritic cells (DC) and potently activat...

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Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Mosaheb, Mubeen, Landi, Daniel, Dobrikova, Elena, Brown, Michael, Yang, Yuanfan, Cable, Jana, Okada, Hideho, Nair, Smita, Bigner, Darell, Ashley, David, Gromeier, Matthias
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Viral/Gene Therapy and other Novel Therapies
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715919/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.855
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