Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma

GBM (glioblastoma multiforme) is the most common and aggressive brain tumor with no curative options available. Therefore, it is imperative to develop novel potent therapeutic drugs for GBM treatment. Here, we show that regorafenib, an oral multi-kinase inhibitor, exhibits superior therapeutic effic...

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Udgivet i:Autophagy
Main Authors: Jiang, Jingwen, Zhang, Lu, Chen, Haining, Lei, Yunlong, Zhang, Tao, Wang, Yuelong, Jin, Ping, Lan, Jiang, Zhou, Li, Huang, Zhao, Li, Bowen, Liu, Yuan, Gao, Wei, Xie, Ke, Zhou, Liangxue, Nice, Edouard C., Peng, Yong, Cao, Yihai, Wei, Yuquan, Wang, Kui, Huang, Canhua
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2019
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6984601/
https://ncbi.nlm.nih.gov/pubmed/30909789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1598752
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