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The secret life of degradative lysosomes in axons: delivery from the soma, enzymatic activity, and local autophagic clearance
Lysosomal degradation of protein aggregates and damaged organelles is essential for maintaining cellular homeostasis. This process in neurons is challenging due to their highly polarized architecture. While enzymatically active degradative lysosomes are enriched in the cell body, their trafficking a...
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| Udgivet i: | Autophagy |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6984450/ https://ncbi.nlm.nih.gov/pubmed/31533518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1669869 |
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