Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity

Neurons face the challenge of maintaining cellular homeostasis through lysosomal degradation. While enzymatically active degradative lysosomes are enriched in the soma, their axonal trafficking and positioning and impact on axonal physiology remain elusive. Here, we characterized axon-targeted deliv...

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Vydáno v:Cell Rep
Hlavní autoři: Farfel-Becker, Tamar, Roney, Joseph C., Cheng, Xiu-Tang, Li, Sunan, Cuddy, Sean R., Sheng, Zu-Hang
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6696943/
https://ncbi.nlm.nih.gov/pubmed/31269450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.06.013
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