Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity

Neurons face the challenge of maintaining cellular homeostasis through lysosomal degradation. While enzymatically active degradative lysosomes are enriched in the soma, their axonal trafficking and positioning and impact on axonal physiology remain elusive. Here, we characterized axon-targeted deliv...

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Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Farfel-Becker, Tamar, Roney, Joseph C., Cheng, Xiu-Tang, Li, Sunan, Cuddy, Sean R., Sheng, Zu-Hang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6696943/
https://ncbi.nlm.nih.gov/pubmed/31269450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.06.013
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