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Non-syndromic Mitral Valve Dysplasia Mutation Changes the Force Resilience and Interaction of Human Filamin A
Filamin A (FLNa), expressed in endocardial endothelia during fetal valve morphogenesis, is key in cardiac development. Missense mutations in FLNa cause non-syndromic mitral valve dysplasia (FLNAMVD). Here, we aimed to reveal the currently unknown underlying molecular mechanism behind FLNA-MVD caused...
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| Publicat a: | Structure |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6984350/ https://ncbi.nlm.nih.gov/pubmed/30344108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2018.09.007 |
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