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Critical Structural Defects Explain Filamin A Mutations Causing Mitral Valve Dysplasia

Mitral valve diseases affect ∼3% of the population and are the most common reasons for valvular surgery because no drug-based treatments exist. Inheritable genetic mutations have now been established as the cause of mitral valve insufficiency, and four different missense mutations in the filamin A g...

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Bibliografiska uppgifter
I publikationen:Biophys J
Huvudupphovsmän: Haataja, Tatu J.K., Capoulade, Romain, Lecointe, Simon, Hellman, Maarit, Merot, Jean, Permi, Perttu, Pentikäinen, Ulla
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Biophysical Society 2019
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6817519/
https://ncbi.nlm.nih.gov/pubmed/31542223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.08.032
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