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Non-syndromic Mitral Valve Dysplasia Mutation Changes the Force Resilience and Interaction of Human Filamin A
Filamin A (FLNa), expressed in endocardial endothelia during fetal valve morphogenesis, is key in cardiac development. Missense mutations in FLNa cause non-syndromic mitral valve dysplasia (FLNAMVD). Here, we aimed to reveal the currently unknown underlying molecular mechanism behind FLNA-MVD caused...
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| 出版年: | Structure |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6984350/ https://ncbi.nlm.nih.gov/pubmed/30344108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2018.09.007 |
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