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Targeting the Mycobacterium tuberculosis transpeptidase Ldt(Mt2) with cysteine-reactive inhibitors including ebselen
The l,d-transpeptidases (Ldts) are promising antibiotic targets for treating tuberculosis. We report screening of cysteine-reactive inhibitors against Ldt(Mt2) from Mycobacterium tuberculosis. Structural studies on Ldt(Mt2) with potent inhibitor ebselen reveal opening of the benzisoselenazolone ring...
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| Publicado no: | Chem Commun (Camb) |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6984337/ https://ncbi.nlm.nih.gov/pubmed/31380528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9cc04145a |
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