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Homeostatic regulation of STING protein at the resting-state by stabilizer TOLLIP

STING is an important innate immune protein, but its homeostatic regulation at the resting-state is unknown. Here, we identified TOLLIP as a stabilizer of STING through direct interaction to prevent its degradation. Tollip-deficiency results in reduced resting-state STING protein level in nonhematop...

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Veröffentlicht in:Nat Immunol
Hauptverfasser: Pokatayev, Vladislav, Yang, Kun, Tu, Xintao, Dobbs, Nicole, Wu, Jianjun, Kalb, Robert G., Yan, Nan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983345/
https://ncbi.nlm.nih.gov/pubmed/31932809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0569-9
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