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Homeostatic regulation of STING protein at the resting-state by stabilizer TOLLIP
STING is an important innate immune protein, but its homeostatic regulation at the resting-state is unknown. Here, we identified TOLLIP as a stabilizer of STING through direct interaction to prevent its degradation. Tollip-deficiency results in reduced resting-state STING protein level in nonhematop...
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| Pubblicato in: | Nat Immunol |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6983345/ https://ncbi.nlm.nih.gov/pubmed/31932809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0569-9 |
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