Inhibition of immune pathway-initiating hemolymph protease-14 by Manduca sexta serpin-12, a conserved mechanism for the regulation of melanization and Toll activation in insects

A network of serine proteases (SPs) and their non-catalytic homologs (SPHs) activates prophenoloxidase (proPO), Toll pathway, and other insect immune responses. However, integration and conservation of the network and its control mechanisms have not yet been fully understood. Here we present evidenc...

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Detalles Bibliográficos
Publicado en:Insect Biochem Mol Biol
Main Authors: Wang, Yang, Yang, Fan, Cao, Xiaolong, Huang, Rudan, Paskewitz, Susan, Hartson, Steve D., Kanost, Michael R., Jiang, Haobo
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983340/
https://ncbi.nlm.nih.gov/pubmed/31698082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ibmb.2019.103261
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