Inhibition of immune pathway-initiating hemolymph protease-14 by Manduca sexta serpin-12, a conserved mechanism for the regulation of melanization and Toll activation in insects

A network of serine proteases (SPs) and their non-catalytic homologs (SPHs) activates prophenoloxidase (proPO), Toll pathway, and other insect immune responses. However, integration and conservation of the network and its control mechanisms have not yet been fully understood. Here we present evidenc...

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Vydáno v:Insect Biochem Mol Biol
Hlavní autoři: Wang, Yang, Yang, Fan, Cao, Xiaolong, Huang, Rudan, Paskewitz, Susan, Hartson, Steve D., Kanost, Michael R., Jiang, Haobo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983340/
https://ncbi.nlm.nih.gov/pubmed/31698082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ibmb.2019.103261
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