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Inhibition of immune pathway-initiating hemolymph protease-14 by Manduca sexta serpin-12, a conserved mechanism for the regulation of melanization and Toll activation in insects

A network of serine proteases (SPs) and their non-catalytic homologs (SPHs) activates prophenoloxidase (proPO), Toll pathway, and other insect immune responses. However, integration and conservation of the network and its control mechanisms have not yet been fully understood. Here we present evidenc...

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Enregistré dans:
Détails bibliographiques
Publié dans:Insect Biochem Mol Biol
Auteurs principaux: Wang, Yang, Yang, Fan, Cao, Xiaolong, Huang, Rudan, Paskewitz, Susan, Hartson, Steve D., Kanost, Michael R., Jiang, Haobo
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983340/
https://ncbi.nlm.nih.gov/pubmed/31698082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ibmb.2019.103261
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