Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden

Fibrous dysplasia of bone (FD) is a mosaic disease caused by mutations in GNAS. Constitutive activation of the α-subunit of the G(s) stimulatory protein (Gαs) leads to dysregulated proliferation of bone marrow stromal cells (BMSCs), generating expansile lesions of fibrotic tissue and abnormal bone....

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Vydáno v:J Bone Miner Res
Hlavní autoři: de Castro, Luis F, Burke, Andrea B, Wang, Howard D, Tsai, Jeffrey, Florenzano, Pablo, Pan, Kristen S, Bhattacharyya, Nisan, Boyce, Alison M, Gafni, Rachel I, Molinolo, Alfredo A, Robey, Pamela G, Collins, Michael T
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983320/
https://ncbi.nlm.nih.gov/pubmed/30496606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3602
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