Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden

Fibrous dysplasia of bone (FD) is a mosaic disease caused by mutations in GNAS. Constitutive activation of the α-subunit of the G(s) stimulatory protein (Gαs) leads to dysregulated proliferation of bone marrow stromal cells (BMSCs), generating expansile lesions of fibrotic tissue and abnormal bone....

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Библиографические подробности
Опубликовано в: :J Bone Miner Res
Главные авторы: de Castro, Luis F, Burke, Andrea B, Wang, Howard D, Tsai, Jeffrey, Florenzano, Pablo, Pan, Kristen S, Bhattacharyya, Nisan, Boyce, Alison M, Gafni, Rachel I, Molinolo, Alfredo A, Robey, Pamela G, Collins, Michael T
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983320/
https://ncbi.nlm.nih.gov/pubmed/30496606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3602
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