Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden

Fibrous dysplasia of bone (FD) is a mosaic disease caused by mutations in GNAS. Constitutive activation of the α-subunit of the G(s) stimulatory protein (Gαs) leads to dysregulated proliferation of bone marrow stromal cells (BMSCs), generating expansile lesions of fibrotic tissue and abnormal bone....

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Detalhes bibliográficos
Publicado no:J Bone Miner Res
Main Authors: de Castro, Luis F, Burke, Andrea B, Wang, Howard D, Tsai, Jeffrey, Florenzano, Pablo, Pan, Kristen S, Bhattacharyya, Nisan, Boyce, Alison M, Gafni, Rachel I, Molinolo, Alfredo A, Robey, Pamela G, Collins, Michael T
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983320/
https://ncbi.nlm.nih.gov/pubmed/30496606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3602
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