GABA(A) Receptor Ligands Often Interact with Binding Sites in the Transmembrane Domain and in the Extracellular Domain—Can the Promiscuity Code Be Cracked?

Many allosteric binding sites that modulate gamma aminobutyric acid (GABA) effects have been described in heteropentameric GABA type A (GABA(A)) receptors, among them sites for benzodiazepines, pyrazoloquinolinones and etomidate. Diazepam not only binds at the high affinity extracellular “canonical”...

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Publicado en:Int J Mol Sci
Autores principales: Iorio, Maria Teresa, Vogel, Florian Daniel, Koniuszewski, Filip, Scholze, Petra, Rehman, Sabah, Simeone, Xenia, Schnürch, Michael, Mihovilovic, Marko D., Ernst, Margot
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6982053/
https://ncbi.nlm.nih.gov/pubmed/31947863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21010334
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