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Metal-assisted synthesis of unsymmetrical magnolol and honokiol analogs and their biological assessment as GABA(A) receptor ligands
We present the synthesis of new derivatives of natural products magnolol (1) and honokiol (2) and their evaluation as allosteric ligands for modulation of GABA(A) receptor activity. New derivatives were prepared via metal assisted cross-coupling reactions in two consecutive steps. Compounds were tes...
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| Pubblicato in: | Bioorg Med Chem Lett |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier Science Ltd
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4297288/ https://ncbi.nlm.nih.gov/pubmed/25510374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.10.091 |
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