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The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates
Proteins are targeted to the proteasome by the attachment of ubiquitin chains, which are markedly varied in structure. Three proteasome subunits–Rpn10, Rpn13, and Rpn1–can recognize ubiquitin chains. Here we report that proteins with single chains of K48-linked ubiquitin are targeted for degradation...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6981147/ https://ncbi.nlm.nih.gov/pubmed/31980598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13906-8 |
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