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The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates

Proteins are targeted to the proteasome by the attachment of ubiquitin chains, which are markedly varied in structure. Three proteasome subunits–Rpn10, Rpn13, and Rpn1–can recognize ubiquitin chains. Here we report that proteins with single chains of K48-linked ubiquitin are targeted for degradation...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Martinez-Fonts, Kirby, Davis, Caroline, Tomita, Takuya, Elsasser, Suzanne, Nager, Andrew R., Shi, Yuan, Finley, Daniel, Matouschek, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981147/
https://ncbi.nlm.nih.gov/pubmed/31980598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13906-8
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