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Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation

Somatic hypermutation (SHM) introduces point mutations into immunoglobulin (Ig) genes but also causes mutations in other parts of the genome. We have used lentiviral SHM reporter vectors to identify regions of the genome that are susceptible (“hot”) and resistant (“cold”) to SHM, revealing that SHM...

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Dettagli Bibliografici
Pubblicato in:Cell Rep
Autori principali: Senigl, Filip, Maman, Yaakov, Dinesh, Ravi K., Alinikula, Jukka, Seth, Rashu B., Pecnova, Lubomira, Omer, Arina D., Rao, Suhas S.P., Weisz, David, Buerstedde, Jean-Marie, Aiden, Erez Lieberman, Casellas, Rafael, Hejnar, Jiri, Schatz, David G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980758/
https://ncbi.nlm.nih.gov/pubmed/31851922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.11.039
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