Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation

Somatic hypermutation (SHM) introduces point mutations into immunoglobulin (Ig) genes but also causes mutations in other parts of the genome. We have used lentiviral SHM reporter vectors to identify regions of the genome that are susceptible (“hot”) and resistant (“cold”) to SHM, revealing that SHM...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Senigl, Filip, Maman, Yaakov, Dinesh, Ravi K., Alinikula, Jukka, Seth, Rashu B., Pecnova, Lubomira, Omer, Arina D., Rao, Suhas S.P., Weisz, David, Buerstedde, Jean-Marie, Aiden, Erez Lieberman, Casellas, Rafael, Hejnar, Jiri, Schatz, David G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980758/
https://ncbi.nlm.nih.gov/pubmed/31851922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.11.039
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