Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation

Somatic hypermutation (SHM) introduces point mutations into immunoglobulin (Ig) genes but also causes mutations in other parts of the genome. We have used lentiviral SHM reporter vectors to identify regions of the genome that are susceptible (“hot”) and resistant (“cold”) to SHM, revealing that SHM...

Full description

Saved in:
Bibliographic Details
Published in:Cell Rep
Main Authors: Senigl, Filip, Maman, Yaakov, Dinesh, Ravi K., Alinikula, Jukka, Seth, Rashu B., Pecnova, Lubomira, Omer, Arina D., Rao, Suhas S.P., Weisz, David, Buerstedde, Jean-Marie, Aiden, Erez Lieberman, Casellas, Rafael, Hejnar, Jiri, Schatz, David G.
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980758/
https://ncbi.nlm.nih.gov/pubmed/31851922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.11.039
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items