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Double-strand breaks in motion: implications for chromosomal rearrangement

DNA double-strand breaks (DSBs) must be rejoined properly to prevent the occurrence of serious genomic rearrangements associated with many human diseases. Non homologous end joining (NHEJ) is a DSB repair mechanism known to protect genomic integrity that is also implicated in creating genomic transl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Curr Genet
Hauptverfasser: Wilson, Thomas E., Sunder, Sham
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980467/
https://ncbi.nlm.nih.gov/pubmed/31321486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00294-019-01015-4
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