(18)F-Trifluoromethanesulfinate Enables Direct C–H (18)F-Trifluoromethylation of Native Aromatic Residues in Peptides

[Image: see text] (18)F labeling strategies for unmodified peptides with [(18)F]fluoride require (18)F-labeled prosthetics for bioconjugation more often with cysteine thiols or lysine amines. Here we explore selective radical chemistry to target aromatic residues applying C–H (18)F-trifluoromethylat...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Kee, Choon Wee, Tack, Osman, Guibbal, Florian, Wilson, Thomas C., Isenegger, Patrick G., Imiołek, Mateusz, Verhoog, Stefan, Tilby, Michael, Boscutti, Giulia, Ashworth, Sharon, Chupin, Juliette, Kashani, Roxana, Poh, Adeline W. J., Sosabowski, Jane K., Macholl, Sven, Plisson, Christophe, Cornelissen, Bart, Willis, Michael C., Passchier, Jan, Davis, Benjamin G., Gouverneur, Véronique
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978814/
https://ncbi.nlm.nih.gov/pubmed/31913613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b11709
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