Radiosynthesis of the anticancer nucleoside analogue Trifluridine using an automated (18)F-trifluoromethylation procedure

Trifluoromethyl groups are widespread in medicinal chemistry, yet there are limited (18)F-radiochemistry techniques available for the production of the complementary PET agents. Herein, we report the first radiosynthesis of the anticancer nucleoside analogue trifluridine, using a fully automated, cl...

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Bibliographic Details
Published in:Org Biomol Chem
Main Authors: King, Alice, Doepner, Andreas, Turton, David, Ciobota, Daniela M., Da Pieve, Chiara, Wong Te Fong, Anne-Christine, Kramer-Marek, Gabriela, Chung, Yuen-Li, Smith, Graham
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2018
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5944245/
https://ncbi.nlm.nih.gov/pubmed/29629716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8ob00432c
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