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Beyond Energy Metabolism: Exploiting the Additional Roles of NAMPT for Cancer Therapy
Tumor cells have increased requirements for NAD(+). Thus, many cancers exhibit an increased reliance on NAD(+) production pathways. This dependence may be exploited therapeutically through pharmacological targeting of NAMPT, the rate-limiting enzyme in the NAD(+) salvage pathway. Despite promising p...
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| Опубликовано в: : | Front Oncol |
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| Главный автор: | |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Frontiers Media S.A.
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6978772/ https://ncbi.nlm.nih.gov/pubmed/32010616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01514 |
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