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Beyond Energy Metabolism: Exploiting the Additional Roles of NAMPT for Cancer Therapy

Tumor cells have increased requirements for NAD(+). Thus, many cancers exhibit an increased reliance on NAD(+) production pathways. This dependence may be exploited therapeutically through pharmacological targeting of NAMPT, the rate-limiting enzyme in the NAD(+) salvage pathway. Despite promising p...

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Détails bibliographiques
Publié dans:Front Oncol
Auteur principal: Heske, Christine M.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978772/
https://ncbi.nlm.nih.gov/pubmed/32010616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01514
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