Differentiation of Pathogenic Th17 Cells Is Negatively Regulated by Let-7 MicroRNAs in a Mouse Model of Multiple Sclerosis

Multiple sclerosis (MS) is a disabling demyelinating autoimmune disorder of the central nervous system (CNS) which is driven by IL-23- and IL-1β-induced autoreactive Th17 cells that traffic to the CNS and secrete proinflammatory cytokines. Th17 pathogenicity in MS has been correlated with the dysreg...

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Udgivet i:Front Immunol
Main Authors: Angelou, Constance C., Wells, Alexandria C., Vijayaraghavan, Jyothi, Dougan, Carey E., Lawlor, Rebecca, Iverson, Elizabeth, Lazarevic, Vanja, Kimura, Motoko Y., Peyton, Shelly R., Minter, Lisa M., Osborne, Barbara A., Pobezinskaya, Elena L., Pobezinsky, Leonid A.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978752/
https://ncbi.nlm.nih.gov/pubmed/32010153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.03125
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