Differentiation of Pathogenic Th17 Cells Is Negatively Regulated by Let-7 MicroRNAs in a Mouse Model of Multiple Sclerosis

Multiple sclerosis (MS) is a disabling demyelinating autoimmune disorder of the central nervous system (CNS) which is driven by IL-23- and IL-1β-induced autoreactive Th17 cells that traffic to the CNS and secrete proinflammatory cytokines. Th17 pathogenicity in MS has been correlated with the dysreg...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Angelou, Constance C., Wells, Alexandria C., Vijayaraghavan, Jyothi, Dougan, Carey E., Lawlor, Rebecca, Iverson, Elizabeth, Lazarevic, Vanja, Kimura, Motoko Y., Peyton, Shelly R., Minter, Lisa M., Osborne, Barbara A., Pobezinskaya, Elena L., Pobezinsky, Leonid A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978752/
https://ncbi.nlm.nih.gov/pubmed/32010153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.03125
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