Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells

The differentiation of naive CD8 T cells into effector cytotoxic T lymphocytes upon antigen stimulation is necessary for successful antiviral, and antitumor immune responses. Here, using a mouse model, we describe a dual role for the let-7 microRNAs in the regulation of CD8 T cell responses, where m...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Wells, Alexandria C, Daniels, Keith A, Angelou, Constance C, Fagerberg, Eric, Burnside, Amy S, Markstein, Michele, Alfandari, Dominique, Welsh, Raymond M, Pobezinskaya, Elena L, Pobezinsky, Leonid A
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550279/
https://ncbi.nlm.nih.gov/pubmed/28737488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26398
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