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3,4-Dihydroxyphenylacetaldehyde Is More Efficient than Dopamine in Oligomerizing and Quinonizing α-Synuclein
Lewy body diseases such as Parkinson’s disease involve intraneuronal deposition of the protein α-synuclein (AS) and depletion of nigrostriatal dopamine (DA). Interactions of AS with DA oxidation products may link these neurohistopathologic and neurochemical abnormalities via two potential pathways:...
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| Gepubliceerd in: | J Pharmacol Exp Ther |
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| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The American Society for Pharmacology and Experimental Therapeutics
2020
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6978699/ https://ncbi.nlm.nih.gov/pubmed/31744850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.262246 |
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