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3,4-Dihydroxyphenylacetaldehyde-Induced Protein Modifications and Their Mitigation by N-Acetylcysteine

The catecholaldehyde hypothesis posits that 3,4-dihydroxyphenylacetaldehyde (DOPAL), an obligate intermediary metabolite of dopamine, is an autotoxin that challenges neuronal homeostasis in catecholaminergic neurons. DOPAL toxicity may involve protein modifications, such as oligomerization of α-synu...

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Bibliografske podrobnosti
izdano v:J Pharmacol Exp Ther
Main Authors: Jinsmaa, Yunden, Sharabi, Yehonatan, Sullivan, Patti, Isonaka, Risa, Goldstein, David S.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988001/
https://ncbi.nlm.nih.gov/pubmed/29700232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.248492
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